InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IARS2

Summary

InnateDB Protein

IDBP-106739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IARS2

Protein Name

isoleucyl-tRNA synthetase 2, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355889

InnateDB Gene

IDBG-106737 (IARS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0003824	catalytic activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004822	isoleucine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006428	isoleucyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002301 Isoleucine-tRNA ligase
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR010663 Zinc finger, DNA glycosylase/AP lyase/isoleucyl tRNA synthetase
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase

PFAM

PF00133
PF06827
PF08264
PF09334

PRINTS

PR00984

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NSE4