InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLX

Summary

InnateDB Protein

IDBP-106777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLX

Protein Name

H2.0-like homeobox

Synonyms

HB24; HLX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000355870

InnateDB Gene

IDBG-106775 (HLX)

Protein Structure

UniProt Annotation

Function

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007519	skeletal muscle tissue development
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045629	negative regulation of T-helper 2 cell differentiation
GO:0046622	positive regulation of organ growth
GO:0048484	enteric nervous system development
GO:0048513	organ development
GO:0048557	embryonic digestive tract morphogenesis