InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIA3

Summary

InnateDB Protein

IDBP-106807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIA3

Protein Name

melanoma inhibitory activity family, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340900

InnateDB Gene

IDBG-106805 (MIA3)

Protein Structure

UniProt Annotation

Function

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. {ECO:0000269PubMed:19269366}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19269366}; Single-pass type I membrane protein {ECO:0000269PubMed:19269366}. Note=Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane.

Disease Associations

Tissue Specificity

Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. {ECO:0000269PubMed:15183315, ECO:0000269PubMed:17044017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002063	chondrocyte development
GO:0002687	positive regulation of leukocyte migration
GO:0006887	exocytosis
GO:0007162	negative regulation of cell adhesion
GO:0015031	protein transport
GO:0030199	collagen fibril organization
GO:0030336	negative regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0042060	wound healing