InnateDB Protein
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IDBP-106819.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MIA3
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Protein Name
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melanoma inhibitory activity family, member 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345866
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InnateDB Gene
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IDBG-106805 (MIA3)
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Protein Structure
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Function |
Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. {ECO:0000269PubMed:19269366}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:19269366}; Single-pass type I membrane protein {ECO:0000269PubMed:19269366}. Note=Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane.
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Disease Associations |
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Tissue Specificity |
Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. {ECO:0000269PubMed:15183315, ECO:0000269PubMed:17044017}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5JRA6
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PhosphoSite |
PhosphoSite-Q5JRA6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
375056
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UniGene |
Hs.708275
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RefSeq |
NP_001287796
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HUGO |
HGNC:24008
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OMIM |
613455
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CCDS |
CCDS73035
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HPRD |
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IMGT |
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EMBL |
AK096526
AK290335
AK296712
AL592148
AY359091
BC047116
D87742
DQ166034
L34688
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GenPept |
AAB00324
AAH47116
AAQ89449
AAZ95512
BAA13448
BAC04810
BAF83024
BAH12416
CAI40469
CAI40470
CAI40471
CAI40473
CAI40474
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