InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIP13

Summary

InnateDB Protein

IDBP-10689.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIP13

Protein Name

thyroid hormone receptor interactor 13

Synonyms

16E1BP;

Species

Homo sapiens

Ensembl Protein

ENSP00000166345

InnateDB Gene

IDBG-10685 (TRIP13)

Protein Structure

UniProt Annotation

Function

Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	87 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0042802	identical protein binding

Biological Process

GO:0001556	oocyte maturation
GO:0006302	double-strand break repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0007130	synaptonemal complex assembly
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007144	female meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0048477	oogenesis
GO:2001141	regulation of RNA biosynthetic process