InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNIH3

Summary

InnateDB Protein

IDBP-106917.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNIH3

Protein Name

cornichon homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000272133

InnateDB Gene

IDBG-106915 (CNIH3)

Protein Structure

UniProt Annotation

Function

Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. {ECO:0000269PubMed:20805473}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269PubMed:23103966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016247	channel regulator activity

Biological Process

GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0042391	regulation of membrane potential
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0016020	membrane
GO:0030054	cell junction
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043198	dendritic shaft
GO:0045211	postsynaptic membrane