InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENAH

Summary

InnateDB Protein

IDBP-106953.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENAH

Protein Name

enabled homolog (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355808

InnateDB Gene

IDBG-106949 (ENAH)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. {ECO:0000269PubMed:15027125}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0050699	WW domain binding

Biological Process

GO:0007411	axon guidance
GO:0046907	intracellular transport
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0045202	synapse