InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHX1

Summary

InnateDB Protein

IDBP-106971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHX1

Protein Name

epoxide hydrolase 1, microsomal (xenobiotic)

Synonyms

EPHX; EPOX; HYL1; MEH;

Species

Homo sapiens

Ensembl Protein

ENSP00000272167

InnateDB Gene

IDBG-106969 (EPHX1)

Protein Structure

UniProt Annotation

Function

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

Subcellular Localization

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Note=In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. {ECO:0000269PubMed:12173035}.Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Found in liver. {ECO:0000269PubMed:12878321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004301	epoxide hydrolase activity
GO:0033961	cis-stilbene-oxide hydrolase activity

Biological Process

GO:0009636	response to toxic substance
GO:0019439	aromatic compound catabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR010497 Epoxide hydrolase, N-terminal
IPR016292 Epoxide hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF06441

PRINTS

PR00111
PR00412

PIRSF

PIRSF001112

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt