Homo sapiens Protein: CDC42BPA | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-107087.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CDC42BPA | ||||||||||||||||||||||
Protein Name | CDC42 binding protein kinase alpha (DMPK-like) | ||||||||||||||||||||||
Synonyms | MRCK; MRCKA; PK428; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000355726 | ||||||||||||||||||||||
InnateDB Gene | IDBG-107075 (CDC42BPA) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269PubMed:11340065, ECO:0000269PubMed:11399775, ECO:0000269PubMed:15723050, ECO:0000269PubMed:18854160, ECO:0000269PubMed:20188707, ECO:0000269PubMed:21457715, ECO:0000269PubMed:9092543, ECO:0000269PubMed:9418861}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269PubMed:9092543}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR000719 Protein kinase domain IPR000961 AGC-kinase, C-terminal IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR014930 Myotonic dystrophy protein kinase, coiled coil IPR017892 Protein kinase, C-terminal IPR017986 WD40-repeat-containing domain IPR020635 Tyrosine-protein kinase, catalytic domain |
||||||||||||||||||||||
PFAM |
PF00786
PF00069 PF00780 PF07714 PF00169 PF00130 PF08826 PF00433 |
||||||||||||||||||||||
PRINTS |
PR00109
|
||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00285
SM00133 SM00036 SM00233 SM00109 SM00220 SM00219 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q5VT25 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q5VT25 | ||||||||||||||||||||||
TrEMBL | Q9NYF6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8476 | ||||||||||||||||||||||
UniGene | Hs.623470 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:1737 | ||||||||||||||||||||||
OMIM | 603412 | ||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | 04562 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB007920 AB208968 AF250871 AJ518975 AJ518976 AL353689 AL451047 AL627308 CR933723 U59305 | ||||||||||||||||||||||
GenPept | AAB37126 AAF66437 BAA32296 BAD92205 CAD57745 CAD57746 CAH71183 CAH71184 CAH71185 CAH71336 CAH71337 CAH71338 CAI19108 CAI19109 CAI19110 CAI19113 CAI46252 | ||||||||||||||||||||||