InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF187

Summary

InnateDB Protein

IDBP-107278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF187

Protein Name

ring finger protein 187

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306396

InnateDB Gene

IDBG-107274 (RNF187)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000269PubMed:20852630}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20852630}. Nucleus {ECO:0000269PubMed:20852630}. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051865	protein autoubiquitination
GO:0070936	protein K48-linked ubiquitination