InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOU

Summary

InnateDB Protein

IDBP-107289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOU

Protein Name

ras homolog gene family, member U

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355652

InnateDB Gene

IDBG-107287 (RHOU)

Protein Structure

UniProt Annotation

Function

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269PubMed:11459829, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058, ECO:0000269PubMed:18086875, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}; Lipid- anchor {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}; Cytoplasmic side {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}. Golgi apparatus membrane {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}; Lipid-anchor {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}. Cell junction, focal adhesion {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}. Cell projection, podosome {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}. Note=Localizes to podosomes in SRC- transformed cells. {ECO:0000269PubMed:16046391, ECO:0000269PubMed:16472646, ECO:0000269PubMed:17620058}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. {ECO:0000269PubMed:11459829, ECO:0000269PubMed:14731133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0002102	podosome
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449
PR00627

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt