InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCSAP

Summary

InnateDB Protein

IDBP-107308.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCSAP

Protein Name

chromosome 1 open reading frame 96

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284617

InnateDB Gene

IDBG-107304 (CCSAP)

Protein Structure

UniProt Annotation

Function

May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:22493317}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:22493317}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:22493317}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:22493317}. Cell projection, axon {ECO:0000269PubMed:22493317}. Cell projection, cilium {ECO:0000269PubMed:22493317}. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007275	multicellular organismal development
GO:0045995	regulation of embryonic development
GO:0060296	regulation of cilium beat frequency involved in ciliary motility

Cellular Component

GO:0005813	centrosome
GO:0005814	centriole
GO:0005819	spindle
GO:0005929	cilium
GO:0005930	axoneme
GO:0030424	axon
GO:0035869	ciliary transition zone
GO:0036064	ciliary basal body