Version 5.4
Homo sapiens Protein: EXOC8
Summary
InnateDB Protein IDBP-107419.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC8
Protein Name exocyst complex component 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355605
InnateDB Gene IDBG-107417 (EXOC8)
Protein Structure
UniProt Annotation
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization Cytoplasm. Cell projection, growth cone {ECO:0000250}. Note=Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0034613 cellular protein localization
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030426 growth cone
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR016159 Cullin repeat-like-containing domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYI6
PhosphoSite PhosphoSite-Q8IYI6
TrEMBL
UniProt Splice Variant
Entrez Gene 149371
UniGene Hs.602432
RefSeq NP_787072
HUGO HGNC:24659
OMIM 615283
CCDS CCDS1593
HPRD 09943
IMGT
EMBL AK096460 AL117352 BC035763 CH471098
GenPept AAH35763 BAG53295 CAI23095 EAW69955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca