Version 5.4
Homo sapiens Protein: TSNAX
Summary
InnateDB Protein IDBP-107436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSNAX
Protein Name translin-associated factor X
Synonyms TRAX;
Species Homo sapiens
Ensembl Protein ENSP00000355599
InnateDB Gene IDBG-107434 (TSNAX)
Protein Structure
UniProt Annotation
Function Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269PubMed:12036294, ECO:0000269PubMed:21552258}.
Subcellular Localization Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008565 protein transporter activity
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0015031 protein transport
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002848 Translin
PFAM PF01997
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99598
PhosphoSite PhosphoSite-Q99598
TrEMBL Q9NRI2
UniProt Splice Variant
Entrez Gene 7257
UniGene Hs.613681
RefSeq NP_005990
HUGO HGNC:12380
OMIM 602964
CCDS CCDS1596
HPRD 04270
IMGT
EMBL AF222988 AF271267 AF271268 AF271269 AK313068 AL136171 AL359543 AL445524 AL450284 AL626763 BC010376 BC011797 CH471098 FJ804222 X95073
GenPept AAF91233 AAH10376 AAH11797 AAK58640 ACR40088 BAG35896 CAA64469 CAH70959 CAH72107 EAW69963 EAW69964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca