InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTPCR

Summary

InnateDB Protein

IDBP-107470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTPCR

Protein Name

nucleoside-triphosphatase, cancer-related

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355587

InnateDB Gene

IDBG-107468 (NTPCR)

Protein Structure

UniProt Annotation

Function

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. {ECO:0000269PubMed:17291528}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0044822	poly(A) RNA binding
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides

Biological Process

GO:0016311

dephosphorylation

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR004948 Nucleoside-triphosphatase, THEP1 type
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03266
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BSD7