InnateDB Protein
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IDBP-107515.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IRF2BP2
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Protein Name
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interferon regulatory factor 2 binding protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355568
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InnateDB Gene
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IDBG-107513 (IRF2BP2)
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Protein Structure
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Function |
Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. {ECO:0000269PubMed:12799427, ECO:0000269PubMed:20702774, ECO:0000269PubMed:21576369}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR022750
Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
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PFAM |
PF11261
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z5L9
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PhosphoSite |
PhosphoSite-Q7Z5L9
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TrEMBL |
B4DTU9
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UniProt Splice Variant |
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Entrez Gene |
359948
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UniGene |
Hs.705869
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RefSeq |
NP_892017
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HUGO |
HGNC:21729
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OMIM |
615332
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CCDS |
CCDS1602
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HPRD |
17160
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IMGT |
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EMBL |
AK300375
AL160408
AY278023
AY278024
BC020516
BC065759
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GenPept |
AAH20516
AAH65759
AAP78944
AAP78945
BAG62111
CAI22767
CAI22768
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