Version 5.4
Homo sapiens Protein: IRF2BP2
Summary
InnateDB Protein IDBP-107517.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF2BP2
Protein Name interferon regulatory factor 2 binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355569
InnateDB Gene IDBG-107513 (IRF2BP2)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. {ECO:0000269PubMed:12799427, ECO:0000269PubMed:20702774, ECO:0000269PubMed:21576369}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
PFAM PF11261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z5L9
PhosphoSite PhosphoSite-Q7Z5L9
TrEMBL B4DTU9
UniProt Splice Variant
Entrez Gene 359948
UniGene Hs.705869
RefSeq NP_001070865
HUGO HGNC:21729
OMIM 615332
CCDS CCDS41475
HPRD 17160
IMGT
EMBL AK300375 AL160408 AY278023 AY278024 BC020516 BC065759
GenPept AAH20516 AAH65759 AAP78944 AAP78945 BAG62111 CAI22767 CAI22768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca