InnateDB Protein
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IDBP-10753.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SULT4A1
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Protein Name
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sulfotransferase family 4A, member 1
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Synonyms
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BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1; NST; SULTX3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000332565
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InnateDB Gene
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IDBG-10751 (SULT4A1)
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Protein Structure
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Function |
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269PubMed:17425406}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030). {ECO:0000269PubMed:10698717, ECO:0000269PubMed:12039030}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BR01
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PhosphoSite |
PhosphoSite-Q9BR01
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TrEMBL |
B7Z320
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UniProt Splice Variant |
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Entrez Gene |
25830
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UniGene |
Hs.607680
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RefSeq |
NP_055166
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HUGO |
HGNC:14903
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OMIM |
608359
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CCDS |
CCDS14051
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HPRD |
07462
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IMGT |
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EMBL |
AF115311
AF176342
AF188698
AF251263
AK295399
AK313048
AL590119
BC022459
BC028171
BC030665
CH471138
CR456588
Z97055
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GenPept |
AAF21970
AAF61197
AAF98152
AAH22459
AAH28171
AAH30665
AAK64595
BAG35880
BAH12056
CAB09788
CAC34872
CAG30474
EAW73320
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