InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NID1

Summary

InnateDB Protein

IDBP-107581.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NID1

Protein Name

nidogen 1

Synonyms

NID;

Species

Homo sapiens

Ensembl Protein

ENSP00000264187

InnateDB Gene

IDBG-107579 (NID1)

Protein Structure

UniProt Annotation

Function

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0043236	laminin binding
GO:0043237	laminin-1 binding
GO:0043394	proteoglycan binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0032836	glomerular basement membrane development
GO:0071711	basement membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000716 Thyroglobulin type-1
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR003886 Nidogen, extracellular domain
IPR006605 G2 nidogen/fibulin G2F
IPR009017 Green fluorescent protein

PFAM

PF00058
PF00086
PF00008
PF07645
PF06119
PF07474

PRINTS

PIRSF

SMART

SM00135
SM00211
SM00181
SM00179
SM00539
SM00682

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14543