InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERO1LB

Summary

InnateDB Protein

IDBP-107591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERO1LB

Protein Name

ERO1-like beta (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346635

InnateDB Gene

IDBG-107589 (ERO1LB)

Protein Structure

UniProt Annotation

Function

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269PubMed:11707400, ECO:0000269PubMed:21091435}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10818100}; Peripheral membrane protein {ECO:0000269PubMed:10818100}; Lumenal side {ECO:0000269PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues. {ECO:0000269PubMed:10818100, ECO:0000269PubMed:16012172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0019471	4-hydroxyproline metabolic process
GO:0022417	protein maturation by protein folding
GO:0030070	insulin processing
GO:0030198	extracellular matrix organization
GO:0042593	glucose homeostasis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process