Version 5.4
Homo sapiens Protein: CREB5
Summary
InnateDB Protein IDBP-10761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB5
Protein Name cAMP responsive element binding protein 5
Synonyms CRE-BPA;
Species Homo sapiens
Ensembl Protein ENSP00000350359
InnateDB Gene IDBG-10759 (CREB5)
Protein Structure
UniProt Annotation
Function Binds to the cAMP response element and activates transcription. {ECO:0000269PubMed:8378084}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0045444 fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060612 adipose tissue development
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004827 Basic-leucine zipper domain
IPR007087 Zinc finger, C2H2
IPR016378 Transcription factor, cyclic AMP-dependent
PFAM PF00170
PF07716
PF00096
PRINTS
PIRSF PIRSF003153
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02930
PhosphoSite PhosphoSite-Q02930
TrEMBL H9KVC5
UniProt Splice Variant
Entrez Gene 9586
UniGene Hs.607561
RefSeq NP_878901
HUGO HGNC:16844
OMIM
CCDS CCDS5417
HPRD 09896
IMGT
EMBL AB451409 AC003074 AC005013 AC005105 AC006331 AC006367 AC006980 AK292916 AK300455 AK316187 BC059400 CH471073 L05515 L05911 L05912 L05913
GenPept AAA52072 AAC37525 AAC37526 AAC37527 AAH59400 AAP22329 AAS00387 BAF85605 BAG62175 BAG70223 BAH14558 EAW93908 EAW93910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca