InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RYR2

Summary

InnateDB Protein

IDBP-107653.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYR2

Protein Name

ryanodine receptor 2 (cardiac)

Synonyms

ARVC2; ARVD2; RyR; RYR-2; VTSIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000353174

InnateDB Gene

IDBG-107649 (RYR2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000699 RIH (RyR and IP3R Homology) domain
IPR001870 B30.2/SPRY domain
IPR002048 EF-hand domain
IPR003032 Ryanodine receptor Ryr
IPR003877 SPRY domain
IPR005821 Ion transport domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009460 Ryanodine Receptor TM 4-6
IPR013333 Ryanodine receptor
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM