InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRM3

Summary

InnateDB Protein

IDBP-107663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRM3

Protein Name

cholinergic receptor, muscarinic 3

Synonyms

EGBRS; HM3;

Species

Homo sapiens

Ensembl Protein

ENSP00000255380

InnateDB Gene

IDBG-107659 (CHRM3)

Protein Structure

UniProt Annotation

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269PubMed:7565628}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Disease Associations

Eagle-Barrett syndrome (EGBRS) [MIM:100100]: A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. {ECO:0000269PubMed:22077972}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0016907	G-protein coupled acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0003056	regulation of vascular smooth muscle contraction
GO:0006112	energy reserve metabolic process
GO:0006464	cellular protein modification process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007399	nervous system development
GO:0007586	digestion
GO:0008283	cell proliferation
GO:0019229	regulation of vasoconstriction
GO:0044281	small molecule metabolic process
GO:0045987	positive regulation of smooth muscle contraction
GO:0046541	saliva secretion
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0043679	axon terminus
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000995 Muscarinic acetylcholine receptor family
IPR001183 Muscarinic acetylcholine receptor M3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00243
PR00540

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20309