InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GREM2

Summary

InnateDB Protein

IDBP-107673.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GREM2

Protein Name

gremlin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318650

InnateDB Gene

IDBG-107671 (GREM2)

Protein Structure

UniProt Annotation

Function

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008201	heparin binding
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0010172	embryonic body morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030509	BMP signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0038098	sequestering of BMP from receptor via BMP binding
GO:0048263	determination of dorsal identity
GO:0060300	regulation of cytokine activity