Version 5.4
Homo sapiens Protein: MYEF2
Summary
InnateDB Protein IDBP-10802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYEF2
Protein Name myelin expression factor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000316950
InnateDB Gene IDBG-10800 (MYEF2)
Protein Structure
UniProt Annotation
Function Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0014902 myotube differentiation
GO:0030182 neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2K5
PhosphoSite PhosphoSite-Q9P2K5
TrEMBL A0A024R5Q6
UniProt Splice Variant
Entrez Gene 50804
UniGene Hs.693247
RefSeq NP_057216
HUGO HGNC:17940
OMIM
CCDS CCDS32230
HPRD 14794
IMGT
EMBL AB037762 AC066612 AC090526 AF190159 AK002075 AK023133 BC014533 BC068523 BC152420 BC152451 CH471082
GenPept AAH14533 AAH68523 AAI52421 AAI52452 AAQ13703 BAA92070 BAA92579 BAB14421 EAW77339 EAW77340 EAW77342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca