InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K9

Summary

InnateDB Protein

IDBP-10861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K9

Protein Name

mitogen-activated protein kinase kinase kinase 9

Synonyms

MEKK9; MLK1; PRKE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000370649

InnateDB Gene

IDBG-10857 (MAP3K9)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR016137 Regulator of G protein signalling superfamily
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00109
PR00452

PIRSF

PIRSF000556

SMART

SM00326
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References