Version 5.4
Homo sapiens Protein: SRRM2
Summary
InnateDB Protein IDBP-10880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRRM2
Protein Name serine/arginine repetitive matrix 2
Synonyms 300-KD; Cwc21; CWF21; SRL300; SRm300;
Species Homo sapiens
Ensembl Protein ENSP00000301740
InnateDB Gene IDBG-10878 (SRRM2)
Protein Structure
UniProt Annotation
Function Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA. {ECO:0000250, ECO:0000269PubMed:10668804}.
Subcellular Localization Nucleus speckle.
Disease Associations
Tissue Specificity Expressed in liver, placenta, and white blood cells. {ECO:0000269PubMed:11004489}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 227 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 227 [view]
Protein-Protein 224 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR013170 mRNA splicing factor, Cwf21
PFAM PF08312
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UQ35
PhosphoSite PhosphoSite-Q9UQ35
TrEMBL I3L4D8
UniProt Splice Variant
Entrez Gene 23524
UniGene Hs.728409
RefSeq NP_057417
HUGO HGNC:16639
OMIM 606032
CCDS CCDS32373
HPRD 06913
IMGT
EMBL AB002322 AB015644 AB016087 AB016089 AB016090 AB016091 AB016092 AC092117 AF161338 AF201422 BC007752 BC009062 BC041155 BC070050 CH471112
GenPept AAF21439 AAF28898 AAH07752 AAH09062 AAH41155 AAH70050 BAA20782 BAA34957 BAA83713 BAA83715 BAA83716 BAA83717 BAA83718 EAW85477 EAW85478 EAW85480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca