Version 5.4
Homo sapiens Protein: SLC6A18
Summary
InnateDB Protein IDBP-10915.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A18
Protein Name solute carrier family 6, member 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323549
InnateDB Gene IDBG-10911 (SLC6A18)
Protein Structure
UniProt Annotation
Function Functions as a sodium and chloride-dependent neutral amino acid transporter. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Note=Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20.
Tissue Specificity Abundantly expressed in kidney, but not in intestine. {ECO:0000269PubMed:15286787}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002438 Sodium:neurotransmitter symporter, orphan
PFAM PF00209
PRINTS PR00176
PR01206
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96N87
PhosphoSite PhosphoSite-Q96N87
TrEMBL
UniProt Splice Variant
Entrez Gene 348932
UniGene Hs.213284
RefSeq NP_872438
HUGO HGNC:26441
OMIM 610300
CCDS CCDS3860
HPRD 15396
IMGT
EMBL AC114291 AK055798 BC056757
GenPept AAH56757 BAB71018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca