Version 5.4
Homo sapiens Protein: ARHGAP8
Summary
InnateDB Protein IDBP-11044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP8
Protein Name Rho GTPase activating protein 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337287
InnateDB Gene IDBG-409020 (ARHGAP8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001251 CRAL-TRIO domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00650
PF13716
PRINTS
PIRSF
SMART SM00324
SM00516
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P85298
PhosphoSite PhosphoSite-P85298
TrEMBL B1AHC2
UniProt Splice Variant
Entrez Gene 23779
UniGene Hs.720401
RefSeq NP_001185655
HUGO HGNC:677
OMIM 609405
CCDS CCDS56233
HPRD 06448
IMGT
EMBL AK001306 AK022305 BC067824 Z83838 Z93244 Z98743
GenPept BAA91614 BAB14008

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca