InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP8

Summary

InnateDB Protein

IDBP-11050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP8

Protein Name

Rho GTPase activating protein 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374424

InnateDB Gene

IDBG-409020 (ARHGAP8)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined. {ECO:0000269PubMed:15225876}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0070374	positive regulation of ERK1 and ERK2 cascade