Version 5.4
Homo sapiens Protein: ZNRF2
Summary
InnateDB Protein IDBP-11071.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNRF2
Protein Name zinc and ring finger 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323879
InnateDB Gene IDBG-11069 (ZNRF2)
Protein Structure
UniProt Annotation
Function May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269PubMed:14561866}.
Subcellular Localization Endosome membrane {ECO:0000269PubMed:14561866}; Peripheral membrane protein {ECO:0000269PubMed:14561866}. Lysosome membrane {ECO:0000269PubMed:14561866}; Peripheral membrane protein {ECO:0000269PubMed:14561866}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:14561866}; Peripheral membrane protein {ECO:0000269PubMed:14561866}. Note=Present in presynaptic plasma membranes in neurons.
Disease Associations
Tissue Specificity Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. {ECO:0000269PubMed:14561866}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0030054 cell junction
GO:0030659 cytoplasmic vesicle membrane
GO:0042734 presynaptic membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHG8
PhosphoSite PhosphoSite-Q8NHG8
TrEMBL
UniProt Splice Variant
Entrez Gene 223082
UniGene Hs.741107
RefSeq NP_667339
HUGO HGNC:22316
OMIM 612061
CCDS CCDS5426
HPRD 15894
IMGT
EMBL AF513707 AF527533
GenPept AAM88868 AAQ08115

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca