InnateDB Protein
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IDBP-11118.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GGCT
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Protein Name
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gamma-glutamylcyclotransferase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000005374
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InnateDB Gene
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IDBG-11114 (GGCT)
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Protein Structure
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Function |
Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269PubMed:16765912, ECO:0000269PubMed:18515354}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003839
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gamma-glutamylcyclotransferase activity
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GO:0042803
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protein homodimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013024
Butirosin biosynthesis, BtrG-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75223
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PhosphoSite |
PhosphoSite-O75223
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79017
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UniGene |
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RefSeq |
NP_001186745
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HUGO |
HGNC:21705
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OMIM |
137170
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CCDS |
CCDS56475
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HPRD |
12912
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IMGT |
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EMBL |
AC005154
AK315608
BC000625
BC005356
BC013937
BC019243
CH471073
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GenPept |
AAH00625
AAH05356
AAH13937
AAH19243
BAG37977
EAW93950
EAW93952
EAW93953
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