InnateDB Protein
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IDBP-11148.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCAPG
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Protein Name
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non-SMC condensin I complex, subunit G
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000251496
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InnateDB Gene
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IDBG-11146 (NCAPG)
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Protein Structure
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Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269PubMed:11136719}.
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Subcellular Localization |
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. {ECO:0000269PubMed:10910072}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
8
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BPX3
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PhosphoSite |
PhosphoSite-Q9BPX3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64151
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UniGene |
Hs.567567
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RefSeq |
NP_071741
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HUGO |
HGNC:24304
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OMIM |
606280
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CCDS |
CCDS3424
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HPRD |
12097
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IMGT |
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EMBL |
AB013299
AF235023
AF331796
AK022512
AK023147
AK027511
BC000827
BC101476
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GenPept |
AAG30732
AAG49627
AAH00827
AAI01477
BAB14069
BAB14429
BAB21557
BAB55165
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