Version 5.4
Homo sapiens Protein: IQSEC3
Summary
InnateDB Protein IDBP-11175.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQSEC3
Protein Name IQ motif and Sec7 domain 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372292
InnateDB Gene IDBG-11169 (IQSEC3)
Protein Structure
UniProt Annotation
Function Acts as a guanine nucleotide exchange factor (GEF) for ARF1. {ECO:0000269PubMed:17981261}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17981261}.
Disease Associations
Tissue Specificity Expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells. {ECO:0000269PubMed:17981261}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000904 Sec7 domain
PFAM PF00612
PF01369
PRINTS
PIRSF
SMART SM00015
SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPP2
PhosphoSite PhosphoSite-Q9UPP2
TrEMBL
UniProt Splice Variant
Entrez Gene 440073
UniGene Hs.536319
RefSeq NP_056047
HUGO HGNC:29193
OMIM 612118
CCDS CCDS31725
HPRD
IMGT
EMBL AB029033 AC007406 AC026369 AK091953 BC024764 BC042067
GenPept AAH24764 BAA83062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca