InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KREMEN2

Summary

InnateDB Protein

IDBP-11180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KREMEN2

Protein Name

kringle containing transmembrane protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304422

InnateDB Gene

IDBG-11178 (KREMEN2)

Protein Structure

UniProt Annotation

Function

Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity). {ECO:0000250UniProtKB:Q8K1S7}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0016055

Wnt signaling pathway

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR000859 CUB domain
IPR002889 Carbohydrate-binding WSC
IPR013806 Kringle-like fold
IPR013994 Carbohydrate-binding WSC, subgroup
IPR017076 Kremen

PFAM

PF00051
PF00431
PF01822

PRINTS

PIRSF

PIRSF036961

SMART

SM00130
SM00042
SM00321

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt