InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFS6

Summary

InnateDB Protein

IDBP-11307.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFS6

Protein Name

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)

Synonyms

CI-13kA; CI-13kD-A; CI13KDA;

Species

Homo sapiens

Ensembl Protein

ENSP00000274137

InnateDB Gene

IDBG-11303 (NDUFS6)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006631	fatty acid metabolic process
GO:0006936	muscle contraction
GO:0010259	multicellular organismal aging
GO:0022904	respiratory electron transport chain
GO:0035264	multicellular organism growth
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0061458	reproductive system development
GO:0070584	mitochondrion morphogenesis
GO:0072358	cardiovascular system development