Version 5.4
Homo sapiens Protein: CLDN6
Summary
InnateDB Protein IDBP-11317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN6
Protein Name claudin 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328674
InnateDB Gene IDBG-11315 (CLDN6)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells. {ECO:0000250, ECO:0000269PubMed:17804490}.
Subcellular Localization Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. {ECO:0000269PubMed:17804490}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003925 Claudin-6
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01445
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56747
PhosphoSite PhosphoSite-P56747
TrEMBL
UniProt Splice Variant
Entrez Gene 9074
UniGene Hs.690156
RefSeq NP_067018
HUGO HGNC:2048
OMIM 615798
CCDS CCDS10488
HPRD 13070
IMGT
EMBL AF125306 AJ249735 AK075329 AY358480 BC008934 BT007399 CH471112
GenPept AAH08934 AAK02013 AAP36063 AAQ88844 BAG52111 CAB56533 EAW85431 EAW85432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca