Version 5.4
Homo sapiens Protein: TNFRSF12A
Summary
InnateDB Protein IDBP-11332.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF12A
Protein Name tumor necrosis factor receptor superfamily, member 12A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000343894
InnateDB Gene IDBG-11328 (TNFRSF12A)
Protein Structure
UniProt Annotation
Function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269PubMed:11728344}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0061041 regulation of wound healing
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR022316 Tumour necrosis factor receptor 12
PFAM PF12191
PRINTS PR01962
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP84
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 51330
UniGene
RefSeq
HUGO HGNC:18152
OMIM 605914
CCDS
HPRD 05801
IMGT
EMBL AB035480 AB035481 AF191148 BC002718 CH471112
GenPept AAF69108 AAH02718 BAA94792 BAB17850 EAW85429 EAW85430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca