Version 5.4
Homo sapiens Protein: IRX4
Summary
InnateDB Protein IDBP-11337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRX4
Protein Name iroquois homeobox 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000231357
InnateDB Gene IDBG-11333 (IRX4)
Protein Structure
UniProt Annotation
Function Likely to be an important mediator of ventricular differentiation during cardiac development.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in cardiac ventricles.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR003893 Iroquois-class homeodomain protein
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
SM00548
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78413
PhosphoSite PhosphoSite-P78413
TrEMBL
UniProt Splice Variant
Entrez Gene 50805
UniGene
RefSeq NP_057442
HUGO HGNC:6129
OMIM 606199
CCDS CCDS3867
HPRD 09369
IMGT
EMBL AB690778 AB690779 AB690780 AB690781 AF124733 AY335941 BC110912 BC136505 BC136506 CH471102 U90306
GenPept AAB50004 AAF23887 AAI10913 AAI36506 AAI36507 AAQ16547 BAL44219 BAL44220 BAL44221 BAL44222 EAX08138 EAX08139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca