Version 5.4
Homo sapiens Protein: B4GALNT3
Summary
InnateDB Protein IDBP-11418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B4GALNT3
Protein Name beta-1,4-N-acetyl-galactosaminyl transferase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266383
InnateDB Gene IDBG-11416 (B4GALNT3)
Protein Structure
UniProt Annotation
Function Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa. {ECO:0000269PubMed:16728562}.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:16728562}; Single-pass type II membrane protein {ECO:0000269PubMed:16728562}. Note=Localizes to apical Golgi.
Disease Associations
Tissue Specificity Highly expressed in testis, colon and stomach. Weakly expressed in other tissues. {ECO:0000269PubMed:12966086}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008376 acetylgalactosaminyltransferase activity
GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID
InterPro IPR008428 Chondroitin N-acetylgalactosaminyltransferase
IPR011658 PA14
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF05679
PF07691
PRINTS
PIRSF
SMART SM00758
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6L9W6
PhosphoSite PhosphoSite-Q6L9W6
TrEMBL
UniProt Splice Variant
Entrez Gene 283358
UniGene Hs.504416
RefSeq NP_775864
HUGO HGNC:24137
OMIM 612220
CCDS CCDS8504
HPRD 12514
IMGT
EMBL AB089940 AC005844 AC006205 AK097681 AK131277
GenPept BAC05141 BAD02449 BAD18454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca