InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMC1B

Summary

InnateDB Protein

IDBP-11440.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC1B

Protein Name

structural maintenance of chromosomes 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350036

InnateDB Gene

IDBG-11438 (SMC1B)

Protein Structure

UniProt Annotation

Function

Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007062	sister chromatid cohesion
GO:0007126	meiotic nuclear division
GO:0016192	vesicle-mediated transport
GO:0051276	chromosome organization

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0005694	chromosome
GO:0016020	membrane
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex