InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACOT1

Summary

InnateDB Protein

IDBP-11555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOT1

Protein Name

acyl-CoA thioesterase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311224

InnateDB Gene

IDBG-11553 (ACOT1)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16940157}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016787	hydrolase activity
GO:0016790	thiolester hydrolase activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002925 Dienelactone hydrolase
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01738
PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86TX2