InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACOT2

Summary

InnateDB Protein

IDBP-11571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOT2

Protein Name

acyl-CoA thioesterase 2

Synonyms

CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128;

Species

Homo sapiens

Ensembl Protein

ENSP00000238651

InnateDB Gene

IDBG-11569 (ACOT2)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. {ECO:0000269PubMed:10944470}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:16940157}.

Disease Associations

Tissue Specificity

Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269PubMed:16940157}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016790	thiolester hydrolase activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49753