InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACOT4

Summary

InnateDB Protein

IDBP-11589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOT4

Protein Name

acyl-CoA thioesterase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323071

InnateDB Gene

IDBG-11587 (ACOT4)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:16940157}.

Disease Associations

Tissue Specificity

Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle. {ECO:0000269PubMed:16940157}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004778	succinyl-CoA hydrolase activity
GO:0005102	receptor binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016790	thiolester hydrolase activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0006104	succinyl-CoA metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0032788	saturated monocarboxylic acid metabolic process
GO:0032789	unsaturated monocarboxylic acid metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0043649	dicarboxylic acid catabolic process
GO:0046459	short-chain fatty acid metabolic process

Cellular Component

GO:0005777

peroxisome

Protein Structure and Domains

PDB ID

InterPro

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N9L9