InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT7B

Summary

InnateDB Protein

IDBP-11695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT7B

Protein Name

wingless-type MMTV integration site family, member 7B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341032

InnateDB Gene

IDBG-11693 (WNT7B)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001944	vasculature development
GO:0003338	metanephros morphogenesis
GO:0007257	activation of JUN kinase activity
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0016332	establishment or maintenance of polarity of embryonic epithelium
GO:0021871	forebrain regionalization
GO:0022009	central nervous system vasculogenesis
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0031175	neuron projection development
GO:0032364	oxygen homeostasis
GO:0032536	regulation of cell projection size
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042592	homeostatic process
GO:0044237	cellular metabolic process
GO:0045165	cell fate commitment
GO:0045669	positive regulation of osteoblast differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046330	positive regulation of JNK cascade
GO:0048144	fibroblast proliferation
GO:0048568	embryonic organ development
GO:0048812	neuron projection morphogenesis
GO:0050808	synapse organization
GO:0051145	smooth muscle cell differentiation
GO:0051384	response to glucocorticoid
GO:0060033	anatomical structure regression
GO:0060070	canonical Wnt signaling pathway
GO:0060425	lung morphogenesis
GO:0060428	lung epithelium development
GO:0060482	lobar bronchus development
GO:0060484	lung-associated mesenchyme development
GO:0060535	trachea cartilage morphogenesis
GO:0060560	developmental growth involved in morphogenesis
GO:0060669	embryonic placenta morphogenesis
GO:0060710	chorio-allantoic fusion
GO:0061180	mammary gland epithelium development
GO:0070307	lens fiber cell development
GO:0071300	cellular response to retinoic acid
GO:0072053	renal inner medulla development
GO:0072054	renal outer medulla development
GO:0072060	outer medullary collecting duct development
GO:0072061	inner medullary collecting duct development
GO:0072089	stem cell proliferation
GO:0072205	metanephric collecting duct development
GO:0072207	metanephric epithelium development
GO:0072236	metanephric loop of Henle development
GO:1902262	apoptotic process involved in patterning of blood vessels

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane