Homo sapiens Protein: AP4E1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-11893.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | AP4E1 | ||||||||||||||||||
Protein Name | adaptor-related protein complex 4, epsilon 1 subunit | ||||||||||||||||||
Synonyms | CPSQ4; SPG51; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000261842 | ||||||||||||||||||
InnateDB Gene | IDBG-11891 (AP4E1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | ||||||||||||||||||
Subcellular Localization | Golgi apparatus, trans-Golgi network. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. | ||||||||||||||||||
Disease Associations | Cerebral palsy, spastic quadriplegic 4 (CPSQ4) [MIM:613744]: A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication. {ECO:0000269PubMed:20972249}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Widely expressed. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002553
Clathrin/coatomer adaptor, adaptin-like, N-terminal IPR011710 Coatomer beta subunit, C-terminal IPR016024 Armadillo-type fold IPR017109 Adaptor protein complex AP-4, epsilon subunit |
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PFAM |
PF01602
PF07718 |
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PRINTS | |||||||||||||||||||
PIRSF |
PIRSF037097
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SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UPM8 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UPM8 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 23431 | ||||||||||||||||||
UniGene | Hs.644559 | ||||||||||||||||||
RefSeq | NP_031373 | ||||||||||||||||||
HUGO | HGNC:573 | ||||||||||||||||||
OMIM | 607244 | ||||||||||||||||||
CCDS | CCDS32240 | ||||||||||||||||||
HPRD | 06258 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB030653 AC021752 AC022407 AC073964 AF155156 BC126308 BC130466 CH471082 CR749604 | ||||||||||||||||||
GenPept | AAD43326 AAI26309 AAI30467 BAA82969 CAH18399 EAW77411 | ||||||||||||||||||