InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPSR1

Summary

InnateDB Protein

IDBP-12097.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPSR1

Protein Name

neuropeptide S receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370950

InnateDB Gene

IDBG-12085 (NPSR1)

Protein Structure

UniProt Annotation

Function

May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269PubMed:15312648, ECO:0000269PubMed:15947423}.

Subcellular Localization

Isoform 1: Cell membrane; Multi-pass membrane protein.Isoform 3: Cell membrane; Multi-pass membrane protein.Isoform 4: Cell membrane; Multi-pass membrane protein.Isoform 2: Cytoplasm.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm.Isoform 7: Cytoplasm.Isoform 9: Cytoplasm.

Disease Associations

Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269PubMed:15073379, ECO:0000269PubMed:15710598, ECO:0000269PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. {ECO:0000269PubMed:15073379, ECO:0000269PubMed:15947423}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005000	vasopressin receptor activity
GO:0008188	neuropeptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001817 Vasopressin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00896

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6W5P4

PhosphoSite

PhosphoSite-Q6W5P4

TrEMBL

UniProt Splice Variant

Entrez Gene

387129

UniGene

Hs.652373

RefSeq

NP_001287864

HUGO

HGNC:23631

OMIM

608595

CCDS

CCDS75579

HPRD

10547

IMGT

EMBL

AK172847 AY310326 AY310327 AY310328 AY310329 AY310330 AY310331 AY310332 AY956446 AY956447 AY956448 BC132693 BC132695 CH471073 DQ272236

GenPept

AAI32694 AAI32696 AAQ76966 AAQ76967 AAQ76968 AAQ76969 AAQ76970 AAQ76971 AAQ76972 AAX63744 AAX63745 AAX63746 ABB72550 BAD18811 EAW94036