InnateDB Protein
|
IDBP-12204.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NKX2-6
|
Protein Name
|
NK2 homeobox 6
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000320089
|
InnateDB Gene
|
IDBG-12202 (NKX2-6)
|
Protein Structure
|
|
Function |
In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000305}.
|
Disease Associations |
Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. {ECO:0000269PubMed:15649947}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
|
PFAM |
PF00046
|
PRINTS |
PR00024
|
PIRSF |
|
SMART |
SM00389
|
TIGRFAMs |
|
Modification |
|
SwissProt |
A6NCS4
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
C9JML6
|
UniProt Splice Variant |
|
Entrez Gene |
137814
|
UniGene |
Hs.532654
|
RefSeq |
NP_001129743
|
HUGO |
HGNC:32940
|
OMIM |
611770
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AC012574
CN272646
|
GenPept |
|
|
|