InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCT5

Summary

InnateDB Protein

IDBP-12330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT5

Protein Name

chaperonin containing TCP1, subunit 5 (epsilon)

Synonyms

CCT-epsilon; CCTE; HEL-S-69; TCP-1-epsilon;

Species

Homo sapiens

Ensembl Protein

ENSP00000280326

InnateDB Gene

IDBG-12328 (CCT5)

Protein Structure

UniProt Annotation

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269PubMed:20080638}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20080638}.

Disease Associations

Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) [MIM:256840]: A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs. {ECO:0000269PubMed:16399879}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	126 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0031681	G-protein beta-subunit binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0009615	response to virus
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR012718 T-complex protein 1, epsilon subunit
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48643