InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YLPM1

Summary

InnateDB Protein

IDBP-12367.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YLPM1

Protein Name

YLP motif containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324463

InnateDB Gene

IDBG-12365 (YLPM1)

Protein Structure

UniProt Annotation

Function

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17890166}. Nucleus speckle {ECO:0000250}. Note=Migrates to nucleolar caps upon blockage of transcription.

Disease Associations

Tissue Specificity

Expressed in neuronal, neuroblastoma and embryonic kidney cell lines (at protein level). {ECO:0000269PubMed:17890166}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008150	biological_process
GO:0032204	regulation of telomere maintenance